Mitochondrial redox signaling and cancer invasiveness
نویسندگان
چکیده
منابع مشابه
Mitochondrial Redox Signaling and Tumor Progression.
Cancer cell can reprogram their energy production by switching mitochondrial oxidative phosphorylation to glycolysis. However, mitochondria play multiple roles in cancer cells, including redox regulation, reactive oxygen species (ROS) generation, and apoptotic signaling. Moreover, these mitochondrial roles are integrated via multiple interconnected metabolic and redox sensitive pathways. Intere...
متن کاملMitochondrial redox control of matrix metalloproteinase signaling in resistance arteries.
The importance of free radicals in the regulation of vascular tone was recognized in the late 1980s, when endothelium-derived relaxing factor was identified to be NO.1,2 More recently, it has become clear that other free radicals, such as superoxide (O2), hydrogen peroxide (H2O2), and peroxynitrite (ONOO-) also modulate vascular reactivity.3,4 However, the exact role of reactive oxygen species ...
متن کاملCell polarity signaling in the plasticity of cancer cell invasiveness
Apico-basal polarity is typical of cells present in differentiated epithelium while front-rear polarity develops in motile cells. In cancer development, the transition from epithelial to migratory polarity may be seen as the hallmark of cancer progression to an invasive and metastatic disease. Despite the morphological and functional dissimilarity, both epithelial and migratory polarity are con...
متن کاملOxidative Stress and Redox-Signaling in Renal Cell Cancer
Worldwide, approximately 150,000 people are diagnosed with Renal Cell Carcinoma (RCC) and 78,000 deaths are reported each year with the incidence on the rise (Jemel et al, 2010). Renal tumors are classified according to the “Heidelberg classification” where the tumors are separated based on their location within the nephron and linked to morphologic and genetic abnormalities (Schullerus et al, ...
متن کاملEscaping Death: Mitochondrial Redox Homeostasis in Cancer Cells
Reactive oxygen species (ROS) are important signaling molecules that act through the oxidation of nucleic acids, proteins, and lipids. Several hallmarks of cancer, including uncontrolled proliferation, angiogenesis, and genomic instability, are promoted by the increased ROS levels commonly found in tumor cells. To counteract excessive ROS accumulation, oxidative stress, and death, cancer cells ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Bioenergetics and Biomembranes
سال: 2012
ISSN: 0145-479X,1573-6881
DOI: 10.1007/s10863-012-9467-7